Objective: This study aimed to determine if personality disorder (PD) predicted functional outcomes in patients with major depressive disorder (MDD). Methods: Data (n=71) from a double-blind, randomized, placebo-controlled 12-week trial assessing the efficacy of 200 mg/day adjunctive minocycline for MDD were examined. PD was measured using the Standardized Assessment of Personality Abbreviated Scale. Outcome measures included Clinical Global Impression – Improvement (CGI-I), Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q), Social and Occupational Functioning Scale (SOFAS), and Range of Impaired Functioning (RIFT). Analysis of covariance was used to examine the impact of PD (dichotomized factor [≥ 3] or continuous measure) on the outcome measures-treatment group correlation. Results: PD was identified in 69% of the sample. After adjusting for age, sex, and baseline scores for each of the outcome measures, there was no significant difference between participants with and without PD on week 12 scores for any of the outcome measures (all p > 0.14). Conclusion: In this secondary analysis of a primary efficacy study, PD was a common comorbidity among those with MDD, but was not a significant predictor of functional outcomes. This study adds to the limited literature on PD in randomized controlled trials for MDD. Clinical trial registration: ACTRN12612000283875.

Abstract: Objectives: To examine both body mass index (BMI) status and waist circunference (WC) in a large international sample of adult Special Olympics participants from Latin America. It also explored the association of age and sex with obesity in this population. Materials and methods: BMI and WC records from a total of 4174 (2683 male and 1491 female) participant records from the Special Olympics International Health Promotion database were examined. Results: The prevalence of overweight and obesity was quite high (i.e. > 40%), but generally lower than studies involving adults with intellectual disabilities from Europe and the USA. Chi-square analyses revealed that both increasing age and being female significantly predicted levels of overweight, obesity, and WC. Conclusions: These results suggest that efforts need to be made to prevent and reduce rates of overweight and obesity among Latin American Special Olympics participants, particularly women.

Resumen: Objetivos: Examinar tanto el estado de índice de masa corporal (IMC) como la circunferencia de cintura (WC) en una muestra significantemente grande de participantes internacionales de Olimpiadas Especiales de América Latina. También este estudio exploró la asociación de la edad y el género con la obesidad en esta población. Material y métodos: Se examinaron los registros de IMC y WC de un total de 4174 (2683 hombres y 1491 mujeres) del banco de datos de la Promoción Internacional de la Salud de Special Olympics (Special Olympics International Health Promotion). Resultados: El predominio de sobrepeso y obesidad fue bastante alta (es decir, > 40%), pero generalmente menor en comparación con los estudios con adultos con discapacidad intelectual de Europa y los Estados Unidos. El análisis Ji cuadrada reveló que tanto el aumento de la edad y ser mujer predijo significativamente los niveles de sobrepeso, obesidad y WC. Conclusiones: Estos resultados sugieren que hay que hacer esfuerzos para prevenir y reducir las tasas de sobrepeso y obesidad entre los participantes de las Olimpiadas Especiales de América Latina, particularmente las mujeres.

Abstract: Objectives: To examine both body mass index (BMI) status and waist circunference (WC) in a large international sample of adult Special Olympics participants from Latin America. It also explored the association of age and sex with obesity in this population. Materials and methods: BMI and WC records from a total of 4174 (2683 male and 1491 female) participant records from the Special Olympics International Health Promotion database were examined. Results: The prevalence of overweight and obesity was quite high (i.e. > 40%), but generally lower than studies involving adults with intellectual disabilities from Europe and the USA. Chi-square analyses revealed that both increasing age and being female significantly predicted levels of overweight, obesity, and WC. Conclusions: These results suggest that efforts need to be made to prevent and reduce rates of overweight and obesity among Latin American Special Olympics participants, particularly women.

Resumen: Objetivos: Examinar tanto el estado de índice de masa corporal (IMC) como la circunferencia de cintura (WC) en una muestra significantemente grande de participantes internacionales de Olimpiadas Especiales de América Latina. También este estudio exploró la asociación de la edad y el género con la obesidad en esta población. Material y métodos: Se examinaron los registros de IMC y WC de un total de 4174 (2683 hombres y 1491 mujeres) del banco de datos de la Promoción Internacional de la Salud de Special Olympics (Special Olympics International Health Promotion). Resultados: El predominio de sobrepeso y obesidad fue bastante alta (es decir, > 40%), pero generalmente menor en comparación con los estudios con adultos con discapacidad intelectual de Europa y los Estados Unidos. El análisis Ji cuadrada reveló que tanto el aumento de la edad y ser mujer predijo significativamente los niveles de sobrepeso, obesidad y WC. Conclusiones: Estos resultados sugieren que hay que hacer esfuerzos para prevenir y reducir las tasas de sobrepeso y obesidad entre los participantes de las Olimpiadas Especiales de América Latina, particularmente las mujeres.